Saquinavir + Loperamide = Precautionary

Effect on Concentration

Saquinavir
Unknown
Applies within class?
No
Loperamide
Increase
Applies within class?
No

Pharmacologic Effects

Saquinavir
Effect
N/A
Applies within class?
No
Loperamide
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The co-administration of saquinavir with loperamide was found to decrease the clearance of loperamide and decrease the plasma concentration of saquinavir in a clinical trial. Based on this study the concomitant use of loperamide and saquinavir without ritonavir is not recommended.

Sources

Loperamide vs saquinavir ^

Study Design

Study Results

Study Conclusions

References

Gerd Mikus, Laila Schmidt, Jrgen Burhenne, Reinhard Ding, Klaus-Dieter Riedel, Yorki Tayrouz, Johanna Weiss, Walter. Emil haefeli. reduction of saquinavir exposure by coadministration of loperamide. Clinical Pharmacokinetics. 2004; 14: 1015-1024.