Tacrolimus + Azithromycin = Precautionary

Effect on Concentration

Tacrolimus
Decrease
Applies within class?
No
Azithromycin
Unknown
Applies within class?
No

Pharmacologic Effects

Tacrolimus
Effect
N/A
Applies within class?
No
Azithromycin
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-May-2020

Summary

Single case report suggest reduced tacrolimus levels due to azithromycin.

Sources

Elevated Tacrolimus Levels Associated With Intravenous Azithromycin and Ceftriaxone: A Case Report ^

Study Design

We describe the case of a heart transplant recipient who developed increased tacrolimus blood levels after the administration of intravenous azithromycin and ceftriaxone.

Study Results

Tacrolimus levels decreased after the discontinuation of ceftriaxone and switch from intravenous to oral azithromycin.

Study Conclusions

Transplant recipients who receive intravenous azithromycin and/or ceftriaxone concomitantly with tacrolimus therapy should be monitored closely for the duration of the antibiotic administration.

References

Shullo MA. Elevated tacrolimus levels associated with intravenous azithromycin and ceftriaxone: a case report. Transplant Proc. 2010; 5: 1870-2.