Azithromycin + Ceftriaxone = Unknown or no reaction

Effect on Concentration

Azithromycin
No change
Applies within class?
No
Ceftriaxone
No change
Applies within class?
No

Pharmacologic Effects

Azithromycin
Effect
N/A
Applies within class?
No
Ceftriaxone
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-May-2020

Summary

No interaction observed between azithromycin and ceftriaxone

Sources

Pharmacokinetics of Intravenous Azithromycin and Ceftriaxone When Administered Alone and Concurrently to Healthy Volunteers ^

Study Design

This randomized, open-label, three-way crossover study in 12 healthy volunteers characterized the plasma pharmacokinetic parameter profiles of both drugs, as well as the white blood cell uptake and exposure to azithromycin, when the drugs were administered alone and together.

Study Results

The plasma pharmacokinetic parameters for azithromycin and ceftriaxone did not differ significantly either after a single dose or at steady state when the two were co-administered as opposed to being administered alone. Moreover, the neutrophil and monocyte/lymphocyte peak azithromycin concentrations and sampling period exposures also did not differ significantly between the study arm and the control arm.

Study Conclusions

This study confirms that there is no interaction between azithromycin and ceftriaxone when they are administered concurrently.

References

Chiu LM. Pharmacokinetics of intravenous azithromycin and ceftriaxone when administered alone and concurrently to healthy volunteers. J Antimicrob Chemother. 2002; 6: 1075-9.