Azithromycin + Indinavir = Unknown or no reaction

Effect on Concentration

Azithromycin
Unknown
Applies within class?
No
Indinavir
No change
Applies within class?
No

Pharmacologic Effects

Azithromycin
Effect
N/A
Applies within class?
No
Indinavir
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-May-2020

Summary

Azithromycin does not alter Indinavir pharmacokinetics

Sources

The Effect of Azithromycin on the Pharmacokinetics of Indinavir ^

Study Design

In an open-label, parallel-design study, 32 healthy male and female volunteers were given indinavir (800 mg tid) for 5 days. One hour prior to the first dose of indinavir on day 5, 18 subjects received 1200 mg azithromycin (Zithromax), and 14 subjects received matching placebo. Serial samples of plasma were obtained for 8 hours following the morning dose of indinavir on days 4 and 5 and assayed for indinavir by HPLC/UV. Twenty-seven subjects completed the study.

Study Results

Following coadministration of azithromycin with indinavir, there was no significant change between day 5 and day 4 in AUC (20.7 mg.hr/ml and 23.1 mg.hr/ml; 90 CI on the ratio 81-100) or Cmax (9.88 mg/ml and 10.3 mg/ml; 90 CI 86-108). The day 5 to day 4 difference in indinavir concentrations following coadministration with azithromycin was not significantly different from the day 5 to day 4 difference with placebo (AUC p 0.68; Cmax p 0.074).

Study Conclusions

Therefore, azithromycin does not significantly alter the kinetics of indinavir.

References

Foulds G. The effect of azithromycin on the pharmacokinetics of indinavir. J Clin Pharmacol. 1999; 8: 842-6.