Hydroxychloroquine + Aspirin = Unknown or no reaction

Effect on Concentration

Hydroxychloroquine
Unknown
Applies within class?
No
Aspirin
Unknown
Applies within class?
No

Pharmacologic Effects

Hydroxychloroquine
Effect
N/A
Applies within class?
No
Aspirin
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 19-May-2020

Summary

Precipitation of serum proteins was used as a chemical marker for inhibition of aspirin esterase activity, predictive of potential aspirin activity, Concentration of aspirin was not evaluated.

Sources

Effect of other drugs and chemicals on the degradation of aspirin in vitro: possible extrapolation to in vivo metabolism of aspirin. ^

Study Design

To assess the possible influence of other drugs and chemicals on the metabolic degradation of aspirin in man, their effect on the serum aspirin esterase activity was determined in vitro. The activation or inhibition of the enzyme as observed with these compounds suggest the possibility that simultaneous ingestion of these drugs with aspirin may influence the pharmacology and toxicity of the analgesic.

Study Results

The action of various drugs and chemicals on the serum aspirin esterase activity was tested as a measure of their possible effect on the metabolic degradation of aspirin in order to elucidate how the interaction between drugs and aspirin may influence aspirins pharmacology and toxicity. The in vitro test used serum as the source of the enzyme which was incubated with soluble aspirin as substrate followed by treatment with an acidic reagent of mercuric chloride and ferric nitrate, which precipitates the serum proteins. The following drugs were found to act as inhibitors of serum aspirin esterase activity: codeine phosphate (50), dextropropoxyphene (Doloxen and Digestic both 50), morphine, methadone, pethidine, papaveretum (all 50), hydroxychloroquine (Plaquenil 50), heparin (50), propanolol (Inderal 50), cimetidien (Tagamet 50), alcohol (50), and ascorbic acid (50). The following drugs were activators of aspirin esterase: calcium (50) and magnesium (50). The following drugs were found inactive: paracetamol, caffeine, phenacetin, phyenylbutazone (Butazolidine), indomethacin (Indocid), cortisone acetate, flufenamic acid (Arlef), mefenamic acid (Ponstan), Ibuprofen (Brufen), dipyridamole (Persantin), warfarin (Coumadin), clofibrate (Atromid), sulphinpyrazone (Anturan), colchincine, allopurinol, diazepam (Valium), oral contraceptives, and sodium cromoglycate (Intal).

Study Conclusions

References

Gupta JD. Effect of other drugs and chemicals on the degradation of aspirin in vitro: possible extrapolation to in vivo metabolism of aspirin. Eur J Drug Metab Pharmacokinet. 1979; 2: 103-8.