Azithromycin + Chloroquine = Unknown or no reaction

Effect on Concentration

Azithromycin
No change
Applies within class?
No
Chloroquine
No change
Applies within class?
No

Pharmacologic Effects

Azithromycin
Effect
N/A
Applies within class?
No
Chloroquine
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 15-May-2020

Summary

There was an absence of clinically relevant pharmacokinetic interaction in a small 24 participant study.

Sources

Lack of a pharmacokinetic interaction between azithromycin and chloroquine ^

Study Design

A study was conducted to investigate a possible pharmacokinetic interaction between azithromycin and chloroquine. Twenty-four subjects received azithromycin, 1,000 mg a day for three days, followed by a washout period, then azithromycin, 1,000 mg plus chloroquine 600 mg base on days 1 and 2, and azithromycin, 1,000 mg plus chloroquine 300 mg base on day 3 of the final period. A second group of 16 subjects received chloroquine, 600 mg base on days 1 and 2, then 300 mg base on day 3.

Study Results

Blood samples were obtained serially up to 624 hours after the day 3 dose in each period. Log transformed maximum concentration and area under the curve values of azithromycin and chloroquine were compared using 90 confidence intervals calculated from appropriate analysis of variance models. Ninety percent confidence intervals for all pharmacokinetic parameters were contained within the interval 80-125

Study Conclusions

There was an absence of clinically relevant pharmacokinetic interaction in a small 24 participant study.

References

Cook, JA. Lack of a pharmacokinetic interaction between azithromycin and chloroquine. Am J Trop Med Hyg. 2006; 3: 407-12..