Lopinavir/Ritonavir + Etonogestrel = Unknown or no reaction

Effect on Concentration

Lopinavir/Ritonavir
No change
Applies within class?
No
Etonogestrel
Increase
Applies within class?
No

Pharmacologic Effects

Lopinavir/Ritonavir
Effect
N/A
Applies within class?
No
Etonogestrel
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 20-Jul-2018

Summary

Sources

Lopinavir/Ritonavir versus Etonogestrel ^

Study Design

This was a non-blinded international study of ARV PK in pregnancy and postpartum. N=26 post-partum women who desired to use etonogestrel (ENG) implant while subsequently taking ARV regimens for at least 2 weeks. PK sampling was taken before 6 to 7 weeks after insertion.

Study Results

Increases in Cmax, Cmin and AUC of progestin were seen after combined use of these products

Study Conclusions

Per the authors, co-administration still resulted in adequate ENG concentrations as well as no significant change in LPV/r exposure, implying that there should not be a change in efficacy of the implant or the ARV therapy.

References

Kreitchman, Stek, Best, Capparelli. Interaction between etonogestrel-releasing implant and 3 antiretroviral regimens [abstract]. Conference On Retroviruses And Opportunistic Infections. Seattle, WA, USA. 2017; February 2017.