Bedaquiline + Kanamycin = Precautionary

Effect on Concentration

Bedaquiline
Increase
Applies within class?
No
Kanamycin
Unknown
Applies within class?
No

Pharmacologic Effects

Bedaquiline
Effect
N/A
Applies within class?
No
Kanamycin
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The authors noted that there was a lower mean creatinine clearance in the kanamycin group versus the control group (91mL/min vs. 112mL/min, respectively), and this likely accounted for the observed changes in the AUC. They concluded there was not a clinically relevant drug interaction between kanamycin and bedaquiline.

Sources

Bedaquiline vs kanamycin ^

Study Design

Patients with multidrug resistant tuberculosis (MDR TB) (n=16) received 14 days of bedaquiline 400mg daily or placebo followed by the administration of 1,000mg (normalized daily dose) of kanamycin. Pharmacokinetic parameters were taken over 1 dosing interval.

Study Results

The ratio of the AUC in the study vs control group for kanamycin was 1.51 (90% CI 1.15 to 1.98).

Study Conclusions

References

R van_Heeswijk, A Diacon, A Pym. The pharmacokinetics (pk) of second line anti-tuberculosis agents with and without tmc207, an investigational antimycobacterial agent, in patients with mdr-tb. abstract a-1258. 52nd Interscience Conference On Antimicrobial Agents And Chemotherapy (icaac). . ; 2012.