Tenofovir Disoproxil Fumarate + Stavudine = Unknown or no reaction

Effect on Concentration

Tenofovir Disoproxil Fumarate
No change
Applies within class?
No
Stavudine
No change
Applies within class?
No

Pharmacologic Effects

Tenofovir Disoproxil Fumarate
Effect
N/A
Applies within class?
No
Stavudine
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 19-Jul-2018

Summary

Sources

Tenofovir Disoproxil Fumarate vs Stavudine ^

Study Design

Pharmacokinetic study described interaction potential between An extended release formulation of stavudine and tenofovir DF. This study took place in healthy adults

Study Results

The pharmacokinetics of stavudine and tenofovir were not affected by coadministration. Mean stavudine and tenofovir Cmax and AUC values were nearly identical to values obtained when the drugs were given alone.

Study Conclusions

These results could also be applicable to the immediate release formulation of stavudine, as the pharmacokinetics of these two formulations have been found by the manufacturer to be comparable.

References

Kaul S, Bassi K, Damle B. Stavudine extended release formulation (d4t xr) and tenofovir disoproxil fumarate (tdf): lack of a pharmacokinetic (pk) drug interaction . Conference On Retroviruses And Opportunistic Infections. San Francisco, CA, USA. 11; February 2004.