Raltegravir + Telaprevir = Precautionary

Effect on Concentration

Raltegravir
Increase
Applies within class?
No
Telaprevir
No change
Applies within class?
No

Pharmacologic Effects

Raltegravir
Effect
N/A
Applies within class?
No
Telaprevir
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

No dose adjustment is recommended for the use of raltegravir and telaprevir.

Sources

Raltegravir vs telaprevir ^

Study Design

In this open-label, cross-over study, 20 healthy, HIV-negative male volunteers were administered telaprevir 750 mg TID alone, raltegravir 400 mg BID alone, and both dosing regimens simultaneously. PK sampling was performed for both drugs.

Study Results

Telaprevir increased raltegravir Cmin 78%, Cmax 26% and AUC 31%. The change in Cmax was not statistically significant, and none of the changes are likely to be clinically relevant.In the presence of raltegravir, telaprevir Cmin increased 14%, and Cmax and AUC did not change significantly.

Study Conclusions

References

R van_Heeswijk, V Garg, G Boogaerts, A Vandebosch, D Luo, J Witek, B Dannemann. The pharmacokinetic interaction between telaprevir and raltegravir in healthy volunteers. 51st Interscience Conference On Antimicrobial Agents And Chemotherapy. Chicago, IL, USA. ; 2012.