Simeprevir + Escitalopram = Unknown or no reaction

Effect on Concentration

Simeprevir
Decrease
Applies within class?
No
Escitalopram
No change
Applies within class?
No

Pharmacologic Effects

Simeprevir
Effect
N/A
Applies within class?
No
Escitalopram
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 18-Jul-2018

Summary

Sources

Simeprevir versus Escitalopram ^

Study Design

Drug–drug interactions between escitalopram and simeprevir were evaluated in 20 healthy male subjects in a randomized, open-label, three-period crossover study with washout periods of at least 10 days between study periods. Subjects received simeprevir (150 mg once daily), escitalopram (10 mg once daily) or simeprevir (150 mg once daily) plus escitalopram (10 mg once daily) for 7 days; all treatments were given under fed conditions .

Study Results

Pharmacokinetic parameters for escitalopram were unchanged with coadministration in comparison with escitalopram alone. Overall, the decrease in simeprevir exposure seen with escitalopram exposure is not clinically relevant. Drug Effect on PK PK Parameters Cmax AUC Cmin Simeprevir Decrease 0.8 (0.71 – 0.89) 0.75 (0.68 – 0.83) 0.68 (0.59 – 0.79) Escitalopram No change 1.03 (0.99 – 1.07) 1 (0.97 – 1.03) 1 (0.95 – 1.05)

Study Conclusions

The authors concluded that there is no clinically significant drug interaction between medications can be administered concomitantly without dose adjustment.

References

Ouwerkerk Mahadevan S, Snoeys J, Peeters M, Beaumont Mauviel M, Simion A. Drug–drug interactions with the ns3/4a protease inhibitor simeprevir. Clinical Pharmacokinetics. 2016; 2: 197-208.