Simeprevir + Caffeine = Unknown or no reaction

Effect on Concentration

Simeprevir
No change
Applies within class?
No
Caffeine
No change
Applies within class?
No

Pharmacologic Effects

Simeprevir
Effect
N/A
Applies within class?
No
Caffeine
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 18-Jul-2018

Summary

Sources

Simeprevir versus Caffeine ^

Study Design

The effect of simeprevir on the CYP system was clinically evaluated in a phase I, two-period, open-label, randomized, crossover trial, which utilized five representative CYP probes. In this trial, 16 healthy subjects (five male) received a drug cocktail that included caffeine 150 mg alone or in combination with 150 mg of simeprevir under fed conditions.

Study Results

The presence of simeprevir resulted in increased exposure to oral caffeine (the Cmax and AUClast increased by 1.12- and 1.26-fold, respectively). Additionally, there was a 1.34-fold increase in the parent drug to metabolite ratio of caffeine.

Study Conclusions

The authors concluded that there was no clinically significant drug interaction with simeprevir and substrates of CYP1A2, including caffeine, and that these drugs may be coadministered without dose adjustments.

References

V Sekar, R Verloes, P Meyvisch. Evaluation of metabolic interactions for tmc435 via cytochrome p450 (cyp) enzymes in healthy volunteers [poster]. presented at: 45th annual meeting of the european association for the. Study Of The Liver (easl); April. Vienna. ; 1418.