Simeprevir + Warfarin = Unknown or no reaction

Effect on Concentration

Simeprevir
No change
Applies within class?
No
Warfarin
No change
Applies within class?
No

Pharmacologic Effects

Simeprevir
Effect
N/A
Applies within class?
No
Warfarin
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 18-Jul-2018

Summary

Sources

Simeprevir versus Warfarin ^

Study Design

The effect of simeprevir on the CYP system was clinically evaluated in a phase I, two-period, open-label, randomized, crossover trial, which utilized five representative CYP probes. In this trial, 16 healthy subjects (five male) received a drug cocktail that included warfarin 10 mg alone or in combination with 150 mg of simeprevir under fed conditions.

Study Results

Simeprevir coadministration resulted in little to no change in exposure to warfarin (Cmax and AUC increased by 1 and 1.04 fold, respectively.

Study Conclusions

The authors concluded that there was no clinically significant drug interaction with simeprevir and substrates of CYP2C9, including warfarin, and that these drugs may be coadministered without dose adjustments.

References

Ouwerkerk Mahadevan S, Snoeys J, Peeters M, Beaumont Mauviel M, Simion A. Drug–drug interactions with the ns3/4a protease inhibitor simeprevir. Clinical Pharmacokinetics. 2016; 2: 197-208.