Etravirine + Ranitidine = Precautionary

Effect on Concentration

Etravirine
Decrease
Applies within class?
No
Ranitidine
Decrease
Applies within class?
No

Pharmacologic Effects

Etravirine
Effect
N/A
Applies within class?
No
Ranitidine
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

A single dose of etravirine (ETV) 100mg was given to healthy subjecs during the first period of a 3 period one-way cross-over study; period 2 was an 11 day course of ranitidine 150mg twice daily, with a single dose of ETV 100mg on day 8; period 3 was an 11 day course of omeprazole 40mg once daily, with a single dose of ETV 100mg on day 8. The AUC and Cmax of ETV when co-administered with ranitidine were 86% and 94% respectively compared to ETV alone. The AUC and Cmax of ETV in the presence of omeprazole were 141% and 117% compared to ETV alone. The increased exposure of ETV when co-administered with omeprazole was not found to be clinically significant. No dose adjustments were recommended when ETV is given with H2-antagonists or proton pump inhibitors.[159]

Sources

Ranitidine vs etravirine ^

Study Design

Study Results

Study Conclusions

References

M Scholler-Gyure, et al. Tmc125 bioavailability is not affected by ranitidine and omeprazole. 16th International Aids Conference. Toronto, Ontario. ; 2006.