Etravirine + Telaprevir = Unknown or no reaction

Effect on Concentration

Etravirine
No change
Applies within class?
No
Telaprevir
Decrease
Applies within class?
No

Pharmacologic Effects

Etravirine
Effect
N/A
Applies within class?
No
Telaprevir
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 17-Jul-2018

Summary

Sources

Etravirine versus Telaprevir ^

Study Design

Investigational study involving a total of 33 participants that examined the effect of co-administration of telaprevir and etravirine.

Study Results

Etravirine lowered telaprevir minimum concentration (Cmin) by 25%, maximum concentration (Cmax) by 10%, and 8-hour area under the concentration-time curve (AUC) by 16%. None of these modest changes were considered clinically relevant. Telaprevir had no impact on concentrations of etravirine: least square mean (LSM) ratios and 90% confidence intervals for etravirine concentrations with versus without telaprevir were all within 80% to 125%.

Study Conclusions

Interaction seen between telaprevir and etravirine was deemed to not be clinically significant.

References

Kakuda TN, Leopold L, Nijs S, Vandevoorde A, Crauwels HM, Bertelsen KM, Hoetelmans RM. Pharmacokinetic interaction between etravirine or rilpivirine and telaprevir in healthy volunteers: a randomized, two‐way crossover trial. Journal Of Clinical Pharmacology. 2014; 5: 563-573.