Rilpivirine + Methadone = Unknown or no reaction

Effect on Concentration

Rilpivirine
No change
Applies within class?
No
Methadone
No change
Applies within class?
No

Pharmacologic Effects

Rilpivirine
Effect
N/A
Applies within class?
No
Methadone
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 10-Jul-2018

Summary

Sources

Pharmacokinetic interaction study between TMC278, a next-generation NNRTI, and methadone. ^

Study Design

Open-label, single-sequence, add-on drug interaction study in healthy subjects

Study Results

Rilpivirine 25mg once daily, designated in this study as TMC278, was given to HIV-negative subjects on stable methadone maintenance therapy. The active from of methadone, R-methadone, experienced a decrease in the mean Cmin, Cmax, and AUC by 22%, 14%, and 16% respectively as compared with methadone alone.

Study Conclusions

The addition on rilpivirine in standard doses to stable methadone maintenance regimens lead to the decrease of both R- and S-methadone (R-methadone is the active form). The exposure of rilpivirine in these patients remained in the expected range. While no dose adjustments of either drug are recommended, it is important to watch for methadone withdrawal symptoms when administering these agents concomitantly. Methadone dose adjustments may be needed.

References

Crauwels, H., Van Heeswijk, R. P. G., Vandevoorde, A., McNeeley, D. F., Bue. Pharmacokinetic interaction study between tmc278, a next-generation nnrti, and methadone. International Aids Conference. Vienna, Austria. XVIII; July 2010.