Darunavir + Clarithromycin = Precautionary

Effect on Concentration

Darunavir
Decrease
Applies within class?
No
Clarithromycin
Increase
Applies within class?
No

Pharmacologic Effects

Darunavir
Effect
N/A
Applies within class?
No
Clarithromycin
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The co-administration of clarithromycin with darunavir and ritonavir shows a decrease in darunavir AUC (13%) and an increase in clarithromycin AUC (57%). Dosage adjustments of clarithromycin are recommended for those patients with renal impairment with concomitant use of darunavir plus ritonavir: CrCl 30-60mL/min decrease clarithromycin dosage 50% and for CrCl <30mL/min decrease clarithromycin dosage 75%; dose adjustments for this agent is not required for those patients with normal renal function; however clinical monitoring is warranted.

Sources

Clarithromycin vs darunavir/r ^

Study Design

Study Results

Study Conclusions

References

Vanitha J Sekar, Sabrina Spinosa-Guzman, El D Paepe, Martin D Pauw, Tony Vangeneugden, Eric Lefebvre, Richar MW Hoetelmans. . darunavir/ritonavir pharmacokinetics following coadministration with clarithromycin in healthy volunteers. Journal Of Clinical Pharmacology. 2008; 1: 60-65.