Lopinavir/Ritonavir + Buprenorphine/Naloxone = Precautionary

Effect on Concentration

Lopinavir/Ritonavir
Unknown
Applies within class?
No
Buprenorphine/Naloxone
No change
Applies within class?
No

Pharmacologic Effects

Lopinavir/Ritonavir
Effect
N/A
Applies within class?
No
Buprenorphine/Naloxone
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The coadministration of lopinavir/r (LPV/r) with buprenorphine/naloxone did not result in significant changes in the AUC or Cmax of buprenorphine or naloxone. There was also no significant differences in norbuprenorphine (the primary metabolite of buprenorphine) AUC; however, there was a statistically significant increase in its clearance and a statistically significant decrease in its Cmax, without leading to opioid withdrawal. Dose adjustments are not recommended.

Sources

Buprenorphine and naloxone vs lopinavir/r ^

Study Design

Study Results

Study Conclusions

References

D Bruce, A F Moody D, G Morse, L Andrews, S-N Lin, W Fang, Q Ma, G Friedland. Pharmacokinetic interactions between buprenorphine/naloxone and once-daily lopinavir/ritonavir. 17th Conference On Retroviruses And Opportunistic Infection. San Francisco, CA. ; .