Rilpivirine + Daclatasvir = Unknown or no reaction

Effect on Concentration

Rilpivirine
No change
Applies within class?
No
Daclatasvir
No change
Applies within class?
No

Pharmacologic Effects

Rilpivirine
Effect
N/A
Applies within class?
No
Daclatasvir
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 09-Jul-2018

Summary

The manufacturer states no drug-drug interaction is expected when daclatasvir is coadministered with rilpivirine based on the degree of CYP3A4 induction by rilpivirine. Dose adjustment of either agent is not required.

Sources

Rilpivirine vs Daclatasvir ^

Study Design

*This interaction has not been formerly studied, but inferences are drawn from knowledge of the metabolic and transport pathways of each of the drugs.

Study Results

The manufacturer states that coadministration of daclatasvir with inhibitors or inducers of either CYP3A or P-gP may alter daclatasvir concentrations.

Study Conclusions

Inhibitors of P-gP or CYP3A may increase daclatasvir concentrations, while inducers of this enzyme and transport protein may decrease daclatasvir concentrations.

References

Garimella T, You X, Wang R, Huang SP, Kandoussi H, Biffano M, Eley T. A review of daclatasvir drug-drug interactions. Advances In Therapy. 2016; 11: 1867-1884.