Amprenavir + Echinacea = Precautionary

Effect on Concentration

Amprenavir
Decrease
Applies within class?
No
Echinacea
Unknown
Applies within class?
No

Pharmacologic Effects

Amprenavir
Effect
N/A
Applies within class?
No
Echinacea
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Based on the effect of Echinacea on CYP activity, it has been theorized that CYP3A substrates such as protease inhibitors used concomitantly with Echinacea could lead to intra-patient variability in protease inhibitor levels depending on the extract used [99].

Sources

Echinacea vs ARV protease inhibitors ^

Study Design

Study Results

Study Conclusions

References

J Christopher Gorski, Shiew-Mei Huang, Amar Pinto, Mitchell A Hamman, Janna K Hilligoss, Narjis A Zaheer, Mehul Desai, Margaret Miller, Stephen D Hall. The effect of echinacea (echinacea purpurea root) on cytochrome p450 activity in vivo. Clinical Pharmacology And Therapeutics. 2004; 1: 89-100.