Ritonavir + Garlic = Precautionary

Effect on Concentration

Ritonavir
Unknown
Applies within class?
No
Garlic
Unknown
Applies within class?
No

Pharmacologic Effects

Ritonavir
Effect
N/A
Applies within class?
No
Garlic
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Based on the effect of garlic on CYP activity and P-glycoprotein caution should be used with the concomitant use of garlic supplements with protease inhibitors.

Sources

Garlic supplements vs ritonavir ^

Study Design

Study Results

Study Conclusions

References

Brian C Foster, Meredith S Foster, Susan Vandenhoek, Anthony Krantis, Jason W Budzinski, John T Arnason, Keith D Gallicano, Shurjeel Choudri. An in vitro evaluation of human cytochrome p450 3a4 and p-glycoprotein inhibition by garlic. Journal Of Pharmacy And Pharmaceutical Sciences. 2001; 2: 176-84.