Daclatasvir + Warfarin = Unknown or no reaction

Effect on Concentration

Daclatasvir
No change
Applies within class?
No
Warfarin
No change
Applies within class?
No

Pharmacologic Effects

Daclatasvir
Effect
N/A
Applies within class?
No
Warfarin
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 30-Jul-2018

Summary

Sources

Daclatasvir versus Warfarin ^

Study Design

This interaction has not been formally studied, but inferences can be made based upon what is known of the metabolic and transport pathways of these agents.

Study Results

There is no predicted DDI between DCV and warfarin (metabolized primarily by CYP3A4 [R-isomer] and CYP2C9 [S-isomer])

Study Conclusions

Coadministration has not been studied but based on metabolism and clearance a pharmacokinetic interaction is unlikely. No dose adjustment of daclatasvir or warfarin is required. However, close monitoring of INR is recommended as this may change as a result of improved liver function.

References

Garimella T, You X, Wang R, Huang SP, Kandoussi H, Bifano M, Eley T. A review of daclatasvir drug–drug interactions. Advances In Therapy. 2016; 11: 1867-1884.