Indinavir + Risperidone = Precautionary

Effect on Concentration

Indinavir
No change
Applies within class?
No
Risperidone
Increase
Applies within class?
No

Pharmacologic Effects

Indinavir
Effect
N/A
Applies within class?
No
Risperidone
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 26-Jun-2018

Summary

Sources

. Neuroleptic malignant syndrome associated with use of risperidone, ritonavir, and indinavir: a case report. ^

Study Design

Studies describing the pharmacokinetic interaction between risperidone and ritonavir boosted indinavir have not been conducted, but several case reports describe possible clinical outcomes of the concomitant use of these agents.

Study Results

These case reports describe increased risk of neuroleptic malignant syndrome, coma, and extrapyramidal symptoms when these drugs are used in combination.

Study Conclusions

Risperidone is metabolized by CYP2D6 and to a lesser extent by CYP3A4. Indinavir/ritonavir could potentially increase risperidone exposure and a decrease in risperidone dose may be needed. Careful monitoring for clinical safety and efficacy is warranted.

References

Lee SI, Klessmer J, Hirsch BE. Neuroleptic malignant syndrome associated with use of risperidone, ritonavir, and indinavir: a case report. Psychosomatics. 2000; 5: 453-454.