Indinavir + Milk Thistle = Precautionary

Effect on Concentration

Indinavir
Decrease
Applies within class?
No
Milk Thistle
Unknown
Applies within class?
No

Pharmacologic Effects

Indinavir
Effect
N/A
Applies within class?
No
Milk Thistle
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The levels of indinavir were not significantly reduced in the presence of milk thistle (450 mg TID). There was a significant decline of AUC0-8h by 38.5% in the control group (no herb was administered). This indicates that other factors besides the exposure of interest may affect the PK [105].

Sources

Milk thistle vs indinavir ^

Study Design

Study Results

Study Conclusions

References

Edward Mills, Kumanan Wilson, Mike Clarke, Brian Foster, Scott Walker, Beth Rachlis, Nick Degroot, et al. Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis. European Journal Of Clinical Pharmacology. 2005; 1: 1-7.