Maraviroc + Carbamazepine = Precautionary

Effect on Concentration

Maraviroc
Decrease
Applies within class?
No
Carbamazepine
No change
Applies within class?
No

Pharmacologic Effects

Maraviroc
Effect
N/A
Applies within class?
No
Carbamazepine
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 01-Aug-2018

Summary

Sources

Maraviroc versus CYP 3A4 inducers or inhibitors or substrates ^

Study Design

There are no formal interaction studies between these two agents.

Study Results

In data supplied by the manufacturer of maraviroc, rifampin, a CYP3A4 inducer, caused adecrease in maraviroc’s Cmin by 78%, AUC by 64%, and Cmax by 66%. Abel et al found that the AUC and Cmax of maraviroc were reduced by approximately 70% and 50% respectively when co-administered with rifampin.

Study Conclusions

While the manufacturer did not supply specifics on maraviroc levels, they did state a higher dose of maraviroc was recommended due to the CYP3A inducing nature of the following drugs: carbamazepine, phenobarbital, and phenytoin. Furthermore, any medication that is a CYP3A inducer could potentially lower maraviroc levels when co-administered. Consider initiation of maraviroc 600 mg BID.

References

Abel S, et al. Effects of cyp3a4 inducers with and without cyp3a4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. British Journal Of Clinical Pharmacology. 2008; : 38-46.