Darunavir + Sutherlandia = Precautionary

Effect on Concentration

Darunavir
Decrease
Applies within class?
No
Sutherlandia
Unknown
Applies within class?
No

Pharmacologic Effects

Darunavir
Effect
N/A
Applies within class?
No
Sutherlandia
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Two herbal products, Sutherlandia and Hypoxis were shown in vitro to inhibit CYP450 3A4 activity 70-96% and 31-79%, respectively. The co-administration of these herbals with antiretroviral agents may result in early inhibition of drug metabolism and transport followed by decreased drug exposure and possibly antiretroviral failure and/or toxicity. It is noted that extreme caution should be used when administering antiretrovirals with herbals [104].

Sources

ARVs vs sutherlandia or hypoxis ^

Study Design

Study Results

Study Conclusions

References

Edward Mills, Brian C Foster, Rolf van_Heeswijk, Elizabeth Phillips, Kumanan Wilson, Blair Leonard, Kazuhiro Kosuge, Isadore Kanfer. Impact of african herbal medicines on antiretroviral metabolism. Aids. 2005; 1: 95-97.