Maraviroc + Grapefruit Juice = Precautionary

Effect on Concentration

Maraviroc
Increase
Applies within class?
No
Grapefruit Juice
No change
Applies within class?
No

Pharmacologic Effects

Maraviroc
Effect
N/A
Applies within class?
No
Grapefruit Juice
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 01-Aug-2018

Summary

Sources

Maraviroc versus CYP 3A4 inducers or inhibitors or substrates ^

Study Design

There are no formal interaction studies between these two agents.

Study Results

Interaction potential is based on knowledge of pharmacokinetic pathways

Study Conclusions

The magnitude of the potential interaction between maraviroc and grapefruit juice is difficult to predict as the effect of grapefruit juice is concentration, dose and preparation dependent and varies widely across brands, but as grapefruit juice inhibits intestinal CYP3A4 and maraviroc has a moderate intestinal extraction, the interaction is likely to be modest.

References

Abel S, et al. Effects of cyp3a4 inducers with and without cyp3a4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. British Journal Of Clinical Pharmacology. 2008; : 38-46.