Maraviroc + Fluconazole = Unknown or no reaction

Effect on Concentration

Maraviroc
Increase
Applies within class?
No
Fluconazole
No change
Applies within class?
No

Pharmacologic Effects

Maraviroc
Effect
N/A
Applies within class?
No
Fluconazole
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 26-Jun-2018

Summary

Sources

Maraviroc vs Fluconazole Theoretical Interactions ^

Study Design

There is no formal interaction between these two agents.

Study Results

There has been no formal interaction study between these two agents. Limited interaction is expected given the differences in metabolic pathway seen with these two agents. Further, fluconazole is commonly utilized in the treatment of AIDS associated fungal infections, with no clinically significant interaction noted.

Study Conclusions

Possible interactions are theoretical and based upon knowledge of metabolic pathways and effects on drug transport proteins. Maraviroc is a substrate of CYP3A4, and fluconazole is a moderate inhibitor of this enzyme. No dose adjustments are currently recommended and if warranted should be based on clinical monitoring of both safety and efficacy of the combined effect of these agents.

References

Hansten P, Horn J. Cytochrome p450 enzymes and drug interactions, table of cytochrome p450 substrates, inhibitors, inducers and p-glycoprotein, with footnotes., in the top 100 drug interactions - a guide to patient mana. 2007