Lopinavir/Ritonavir + Phenobarbital = Prohibited

Effect on Concentration

Lopinavir/Ritonavir
Decrease
Applies within class?
No
Phenobarbital
Unknown
Applies within class?
No

Pharmacologic Effects

Lopinavir/Ritonavir
Effect
N/A
Applies within class?
No
Phenobarbital
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 30-Jul-2018

Summary

Sources

Drug interactions of HIV protease inhibitors ^

Study Design

The interaction between these two agents has not been formally studied, but based upon known mechanisms of drug metabolism, and package inserts, complex interactions may arise.

Study Results

This information is based upon known mechanisms of drug metabolism, but the study has not been formally studied.

Study Conclusions

Phenobarbital, Phenytoin and Carbamazepine should be used with caution with protease inhibitors. Coadministration has not been studied but is expected to decrease protease inhibitor concentrations.

References

Malaty LI, Kuper JJ. drug interactions of hiv protease inhibitors. Drug Safety. 1999; 2: 147-169.