Etravirine + Voriconazole = Precautionary

Effect on Concentration

Etravirine
Increase
Applies within class?
No
Voriconazole
Unknown
Applies within class?
No

Pharmacologic Effects

Etravirine
Effect
N/A
Applies within class?
No
Voriconazole
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 30-Jul-2018

Summary

Sources

Etravirine versus Voriconazole ^

Study Design

The information presented here stems from the referenced review article based on the medications’ package inserts.

Study Results

Voriconazole increased etravirine exposure by 1.4 fold in healthy subjects, but there was no increase in the incidence of adverse events related to azole antifungals in other studies. Voriconazole may increase etravirine concentrations, though the clinical significance of this interaction is unknown.

Study Conclusions

References

Kakuda TN, Scholler-Gyure M, Hoetelmans RM. Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clinical Pharmacokinetics. 2011; 1: 25-39.