Indinavir + Vitamin C = Precautionary

Effect on Concentration

Indinavir
Decrease
Applies within class?
No
Vitamin C
Unknown
Applies within class?
No

Pharmacologic Effects

Indinavir
Effect
N/A
Applies within class?
No
Vitamin C
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Seven healthy volunteers were given Indinavir 800mg TID (4 doses total) followed by a 7-day washout, then Vitamin C 1000mg/day for 7 days, then Indinavir 800mg TID for 4 doses at the end of the 7 day course of Vitamin C. Vitamin C decreased IDV Cmax and AUC0-8hr by 20 and 14%, respectively (p=0.04 and 0.05, respectively). Mean IDV Cmin was decreased 32%, but not statistically significantly [106].

Sources

Vitamin c vs indinavir ^

Study Design

Study Results

Study Conclusions

References

Douglas Slain, Jarrett R Amsden, Rashida A Khakoo, Melanie A Fisher, David Lalka, Gerry R Hobbs. Effect of high-dose vitamin c on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy: The Journal Of Human Pharmacology And Drug Therapy. 2005; 2: 165-170.