Efavirenz + Milk Thistle = Precautionary

Effect on Concentration

Efavirenz
Increase
Applies within class?
No
Milk Thistle
Unknown
Applies within class?
No

Pharmacologic Effects

Efavirenz
Effect
N/A
Applies within class?
No
Milk Thistle
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Milk thistle might inhibit CYP3A4 and 2C9, so there is potential for an increase in NNRTI concentrations. Thus far, this interaction has not been reported in humans.

Sources

ARVs vs milk thistle ^

Study Design

Study Results

Study Conclusions

References

Raman Venkataramanan, Vinod Ramachandran, Bernard J Komoroski, Shimin Zhang, Paul L Schiff, Stephen C Strom. Milk thistle, a herbal supplement, decreases the activity of cyp3a4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Drug Metabolism And Disposition. 2000; 11: 1270-1273.