Efavirenz + Dapsone = Unknown or no reaction

Effect on Concentration

Efavirenz
No change
Applies within class?
No
Dapsone
No change
Applies within class?
No

Pharmacologic Effects

Efavirenz
Effect
N/A
Applies within class?
No
Dapsone
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 30-Jul-2018

Summary

Sources

NNRTIs versus Dapsone ^

Study Design

The reference is a review article and describes the metabolic pathways of these agents. No research directly studying this interaction has been described, but because dapsone is often used as prophylaxis for various opportunistic infections seen in patients with AIDS, the clinical significance of any possible interaction is expected to be minimal.

Study Results

No results from direct interaction studies have been described.

Study Conclusions

No drug interactions are expected with co-administration of Dapsone and DLV or EFV based on the drugs metabolism. No signification drug interaction is expected with the co-administration of Dapsone and nevirapine base on studies using human liver microsomes.

References

Khoo S, Back D, Winstanley P. The potential for interactions between antimalarial and antiretroviral drugs. Aids. 2005; 10: 995-1005.