Voxilaprevir + Grapefruit Juice = Unknown or no reaction

Effect on Concentration

Voxilaprevir
No change
Applies within class?
No
Grapefruit Juice
Unknown
Applies within class?
No

Pharmacologic Effects

Voxilaprevir
Effect
N/A
Applies within class?
No
Grapefruit Juice
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The authors concluded that when given with food, grapefruit juice would not have an impact on the pharmacokinetic parameters of GS-9857.

Sources

Voxilaprevir vs 5 drugs ^

Study Design

This was an open label, single and multiple dose four cohort study in 98 healthy volunteers. Participants were administered a single dose of GS-9857 100 mg alone or in combination with inhibitors or inducers of drug transporters or CYP isoenzymes. These drugs included rifampin 600 mg x 1 dose fasted, or rifampin 600 mg daily for seven days fed. Geometric means ratios and 90% Confidence Intervals for GS-9857 were estimated and compared to pre-specified lack of PK alteration boundaries 70% - 143%. Safety was assessed by routine laboratory and clinical monitoring. Five subjects discontinued the study drug during the study period.

Study Results

Study data were not given, but the authors concluded that inhibition of intestinal OATP by grapefruit juice on GS-9857 had limited effect when administered with food.

Study Conclusions

References

Kirby BJ, J Taylor, Stamm LM, Q Song, Y Li, A Mathias. Evaluation of pan genotypic hcv ns3/4a protease inhibitor gs-9857 as the object of transporter and cytochrome p450 mediated drug-drug interactions. 17th International Workshop On Clinical Pharmacology Of Hiv And Hepatitis Therapy. Washington, DC, USA. ; 2016.