Lopinavir/Ritonavir + Irinotecan = Precautionary

Effect on Concentration

Lopinavir/Ritonavir
Unknown
Applies within class?
No
Irinotecan
Increase
Applies within class?
No

Pharmacologic Effects

Lopinavir/Ritonavir
Effect
N/A
Applies within class?
No
Irinotecan
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

A 42yo male with Kaposi's sarcoma taking KAL 400/100mg BID was treated with irinotecan (IRN) at 50% of the usual dose due to grade G2 neutropenia. IRN PK profiles were assessed after a 2 day KAL washout and when combined with KAL at steady state. The AUC ratio of IRN inactive metabolite to parent drug was 20-fold lower when given with KAL; IRN clearance decreased 34%; and AUC of the active metabolite increased 2-fold. Caution should be taken when combining IRN and KAL.

Sources

Irinotecan vs lopinavir/r ^

Study Design

Study Results

Study Conclusions

References

Giuseppe Corona, Emanuela Vaccher, Giulio Cattarossi, Ivana Sartor, Giuseppe Toffoli. Potential hazard of pharmacokinetic interactions between lopinavirritonavir protease inhibitors and irinotecan. Aids. 2005; 17: 2043-2044.