Ritonavir + Rosiglitazone = Precautionary

Effect on Concentration

Ritonavir
Unknown
Applies within class?
No
Rosiglitazone
Unknown
Applies within class?
No

Pharmacologic Effects

Ritonavir
Effect
N/A
Applies within class?
No
Rosiglitazone
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The Cmax of rosiglitazone, a CYP2C8 probe, was unaffected by co-administration of atazanavir or atazanavir + ritonavir. Exposure to rosiglitazone was increased by co-administration of atazanavir 400mg daily and decreased by co-administration of atazanavir + ritonavir 300mg/100mg daily. ATV is classified as a weak CYP2C8 inhibitor and ritonavir as a CYP2C8 inducer.

Sources

Atazanavir or ritonavir vs rosiglitazone ^

Study Design

Study Results

Study Conclusions

References

H Sevinsky, et al. Effect of atazanavir with and without ritonavir on the pharmacokinetics of the cyp2c8 probe rosiglitazone in healthy subjects. 9th International Workshop On Clinical Pharmacology Of Hiv Therapy. New Orleans, LA. ; 2008.