Lopinavir/Ritonavir + Esomeprazole = Precautionary

Effect on Concentration

Lopinavir/Ritonavir
No change
Applies within class?
No
Esomeprazole
Unknown
Applies within class?
No

Pharmacologic Effects

Lopinavir/Ritonavir
Effect
N/A
Applies within class?
No
Esomeprazole
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The concomitant use of lopinavir/ritonavir and H2 receptor antagonist and proton pump inhibitors were not found to effect concentrations of lopinavir/ritonavir in limited studies. Acid reducing agents (omeprazole and ranitadine) did not significantly alter LPV or RTV exposure after co-administration with LPV/r 400/100 mg BID or 800/200 mg QD tablets.

Sources

Gastric Acid-Reducing Agents vs Lopinavir/Ritonavir ^

Study Design

Study Results

Study Conclusions

References

Bertz RJ, et al. Lack of effect of gastric acid reducing agents on lopinavir/ritonavir plasma concentrations in hiv-infected patients. 7th International Congress On Drug Therapy In Hiv Infection. Glasgow. ; 2004.