Fosamprenavir + Esomeprazole = Precautionary

Effect on Concentration

Fosamprenavir
No change
Applies within class?
No
Esomeprazole
Unknown
Applies within class?
No

Pharmacologic Effects

Fosamprenavir
Effect
N/A
Applies within class?
No
Esomeprazole
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

56 healthy volunteers participated in a randomized, open-label, two-arm, three-period cross-over study to evaluate the combination of esomeprazole 20mg QD (ESO) and fosamprenavir/ritonavir 700/100mg BID (FPV/RTV) or FPV 1400mg BID. FPV were not changed with the addition of ESO. Only ESO Cmax was increased 55%.

Sources

Esomeprazole vs fosamprenavir ^

Study Design

Study Results

Study Conclusions

References

Shelton MJ, et al. Coadministration of esomeprazole (eso) with fosamprenavir (fpv) has no impact on steady-state plasma amprenavir (apv) pharmacokinetics (apv10031) (abstract 24). 6th International Workshop On Clinical Pharmacology Of Hiv Therapy, April. Quebec City, Quebec. ; 2005.