Etravirine + Echinacea = Unknown or no reaction

Effect on Concentration

Etravirine
No change
Applies within class?
No
Echinacea
Unknown
Applies within class?
No

Pharmacologic Effects

Etravirine
Effect
N/A
Applies within class?
No
Echinacea
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Based on the study results, E. purpurea does not significantly affect the PKs of ETR in HIV-infected patients. The investigators concluded that no dose adjustment for ETR is necessary when co-administering with E. purpurea.

Sources

Echinacea purpurea vs etravirine ^

Study Design

In an open-label, fixed-sequence study, the concomitant use of the botanical supplement, Echinacea purpurea (E. purpurea), and etravirine (ETR) was evaluated in HIV-infected patients (n=15). Patients who had been receiving antiretroviral (ARV) therapy with ETR (400 mg once daily (QD)) for at least 4 weeks received E. purpurea root extracts (500 mg every 8 hours (q8h)) for 14 days. All pills came from a single lot, which was externally controlled and certified to contain 100% of the labeled content of E. purpurea.Plasma samples for analysis of ETR were obtained predose and at 1, 2, 3, 4, 6, 8,10, 12 and 24h after a morning dose of ETR on day 0. Plasma samples for analysis of ETR plus E. purpurea were obtained on day 14.

Study Results

When patients were given ETR (400 mg QD) together with E. purpurea (500 mg q8h) for 14 days, E. purpurea had no significant effect on ETR pharmacokinetic (PK) parameters. The geometric mean ratios (GMRs; E.purpurea + ETR / ETR) [90% CIs] of ETR were: 1.07 [0.81, 1.42] for Cmax, 1.04 [0.79, 1.38] for AUC, and 1.04 [0.74, 1.44] for Cmin.

Study Conclusions

References

Jos Molt, Marta Valle, Cristina Miranda, Samandhy Cedeo, Eugenia Negredo, Bonaventura Clotet. Herb-drug interaction between echinacea purpurea and etravirine in hiv-infected patients. Antimicrobial Agents And Chemotherapy. 2012; 10: 5328-5331.