Danoprevir/Ritonavir + Methadone = Unknown or no reaction

Effect on Concentration

Danoprevir/Ritonavir
Unknown
Applies within class?
No
Methadone
No change
Applies within class?
No

Pharmacologic Effects

Danoprevir/Ritonavir
Effect
N/A
Applies within class?
No
Methadone
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The investigators concluded that DNV/r may be coadministered with methadone without dose adjustment.

Sources

Methadone vs danoprevir/ritonavir ^

Study Design

In single-center, open-label, two-period, single sequence study, 18 hepatitis C virus (HCV)-negative adults on stable opiate maintenance therapy with methadone (20-150 mg daily) received danoprevir/ritonavir (DNV/r) 100/100 mg twice daily for 10 days.

Study Results

Coadministration of DNV/r (100/100mg twice daily) for 10 days did not significantly impact the pharmacokinetics (PK) of both R- (active enantiomer) and S- methadone. Geometric mean ratios (GMRs; DNV/r + methadone / methadone) [90% CIs] of AUC and Cmax for R-methadone were 1.02 [0.91, 1.15] and 1.01 [0.90, 1.13], respectively; GMRs (DNV/r + methadone / methadone) [90% CIs] of AUC and Cmax for S-methadone were 1.01 [0.93, 1.13] and 0.99 [0.89, 1.10], respectively.No symptoms of opiate toxicity or withdrawal were noted.

Study Conclusions

References

Moreira SA, Morcos PN, Navarro MT, et al. No change in steady state pharmacokinetics of methadone after coadministration with danoprevir/ritonavir [abstract pk_10]. 7th Annual International Workshop On Clinical Pharmacology Of Hepatitis Therapy. Cambridge, MA. ; 2012.