Nelfinavir + Omeprazole = Prohibited

Effect on Concentration

Nelfinavir
Decrease
Applies within class?
No
Omeprazole
Unknown
Applies within class?
No

Pharmacologic Effects

Nelfinavir
Effect
N/A
Applies within class?
No
Omeprazole
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

The plasma concentration of nelfinavir and its metabolite, M8, were significantly decreased when co-administered with omeprazole 40 mg po qd. Coadministration of omeprazole and nelfinavir are not recommended.

Sources

Omeprazole vs nelfinavir ^

Study Design

Study Results

Study Conclusions

References

A Fang, et al. Omeprazole (ome) significantly decreases nelfinavir (nfv) systemic exposure in healthy subjects. abstract a-384. 46th Interscience Conference On Antimicrobial Agents And Chemotherapy (icaac). San Fransisco, CA. ; 2006.