Lopinavir/Ritonavir + Fenofibric Acid = Unknown or no reaction

Effect on Concentration

Lopinavir/Ritonavir
Unknown
Applies within class?
No
Fenofibric Acid
No change
Applies within class?
No

Pharmacologic Effects

Lopinavir/Ritonavir
Effect
N/A
Applies within class?
No
Fenofibric Acid
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

LPV/r did not affect FFA PK in healthy volunteers. The investigators concluded that an interaction between FFA and LPV/r is unlikely to occur in HIV-infected patients taking these agents concurrently.

Sources

Fenofibric acid vs lopinavir/r ^

Study Design

Helathy subjects received a single dose of fenofibric acid (FFA) 145mg (Phase 1). Subjects then received two weeks of ritonavir (RTV) 100mg twice daily, followed by a single dose of FFA 145mg (Phase 2). Then, subjects received a single dose of FFA 145mg after two weeks of lopinavir/ritonavir (LPV/r) 400mg/100mg twice daily (Phase 3). After each FFA dose, blood was collected serially over 120 hours and analyzed using high performance liquid chromatography/mass spectrometry (HPLC/MS).

Study Results

LPV/r 400/100 mg twice daily did not have significant effects on the pharmacokinetics (PK) of single-dose FFA 145 mg. When coadminsitered with LPV/r, geometric mean ratios (GMRs; LPV/r+FFA / FFA) [90% CIs] of AUC and Cmax for FFA were 0.86 [0.69, 1.05] and 0.97 [0.79, 1.15], respectively.

Study Conclusions

References

Gordon LA, Malati CY, C Hadigan, et al. Influence of lopinavir/ritonavir and ritonavir alone on the pharmacokinetics of fenofibric acid in healthy volunteers [abstract a-1575]. 53rd Interscience Conference On Antimicrobial Agents And Chemotherapy (icaac). Denver, CO. ; 2013.