Lopinavir/Ritonavir + Ginseng = Unknown or no reaction

Effect on Concentration

Lopinavir/Ritonavir
No change
Applies within class?
No
Ginseng
Unknown
Applies within class?
No

Pharmacologic Effects

Lopinavir/Ritonavir
Effect
N/A
Applies within class?
No
Ginseng
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Neither lopinavir nor ritonavir steady-state PK were altered by 2 weeks of Panax ginseng administration to healthy human volunteers. The investigators concluded that a clinically significant interaction between Panax ginseng and LPV/r is unlikely to occur in HIV-infected patients who choose to take these agents concurrently.

Sources

Lopinavir/r vs panax ginseng ^

Study Design

12 healthy volunteers received lopinavir/ritonavir (LPV/r; 400/100 mg) twice daily for 29.5 days. On Day 15 of LPV/r administration, serial blood samples were collected over 12 hours to determine LPV and ritonavir (RTV) concentrations. On Day 16, subjects received Panax ginseng 500 mg twice daily for 2 weeks in combination with LPV/r. On Day 30, serial blood samples were collected over 12 hours to determine of LPV and RTV concentrations.

Study Results

Coadministration of LPV/r and Panax ginseng did not result in significant changes in pharmacokinetic (PK) parameters of either LPV or RTV. Geometric mean ratios (GMRs; Ginseng+LPV/r / LPV/r) [90% CIs] of AUC and Cmax for LPV were 0.95 [0.85, 1.05] and 0.94 [0.84, 1.04], respectively. GMRs (Ginseng+LPV/r / LPV/r) [90% CIs] of AUC and Cmax for RTV were 0.95 [0.80, 1.09] and 0.92 [0.70, 1.14], respectively.

Study Conclusions

References

Mnica M Caldern, Cheryl L Chairez, Lori A Gordon, Raul M Alfaro, Joseph A Kovacs, Scott R Penzak. Influence of panax ginseng on the steady state pharmacokinetic profile of lopinavir-ritonavir in healthy volunteers. Pharmacotherapy: The Journal Of Human Pharmacology And Drug Therapy. 2014; 11: 1151-1158.