Lopinavir/Ritonavir + Pitavastatin = Unknown or no reaction

Effect on Concentration

Lopinavir/Ritonavir
No change
Applies within class?
No
Pitavastatin
Decrease
Applies within class?
No

Pharmacologic Effects

Lopinavir/Ritonavir
Effect
N/A
Applies within class?
No
Pitavastatin
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Sources

Pitavastatin vs lopinavir/r ^

Study Design

In an open-label one-arm study (n=23), pitavastatin 4 mg was given once daily on days 1-5 and 20-24 with a washout period between administrations. Lopinavir/ritonavir 400mg/100mg was administered twice daily on days 9-24. Plasma samples for PK assessments of pitavastatin were collected on days 5, 19, and 24.

Study Results

DrugAUC GMR (90% CI)Cmax GMR (90% CI)Pitavastatin80.0% (73.4 to 87.3)96.1% (83.6 to 110.4)Lopinavir AUC was decreased by 9% and Cmax by 7% during coadministration with pitavastatin. No clinically significant adverse events were noticed in the study. Concurrent administration of these agents requires no adjustments at this time.

Study Conclusions

References

Roger E Morgan, Stuart E Campbell, Kazuhito Suehira, Craig A Sponseller, Y Yu Christine, Matthew M Medlock. Effects of steady-state lopinavir/ritonavir on the pharmacokinetics of pitavastatin in healthy adult volunteers. Jaids Journal Of Acquired Immune Deficiency Syndromes. 2012; 2: 158-164.