Ledipasvir/Tegobuvir/Vedroprevir + Cyclosporine = Precautionary

Effect on Concentration

Ledipasvir/Tegobuvir/Vedroprevir
Unknown
Applies within class?
No
Cyclosporine
Unknown
Applies within class?
No

Pharmacologic Effects

Ledipasvir/Tegobuvir/Vedroprevir
Effect
N/A
Applies within class?
No
Cyclosporine
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Sources

ledipasvir/sofosbuvir vs pravastatin, rosuvastatin, gigoxin, or cyclosporine ^

Study Design

The drug-drug interaction potential of ledipasvir (LDV) in combination with vedroprevir (VDV) and tegobuvir (TGV) with pravastatin was evaluated.

Study Results

The AUC and Cmax of CsA were unaffected by co-administration with LDV/VDV/TGV (magnitude of changes were not reported).CsA should still be monitored as in standard clinical practice.The pharmacokinetic effect on LDV/VDV/TGV was not reported, use caution.

Study Conclusions

References

P German, Pang PS, L Fang, et al. Drug-drug interaction profile of the fixed dose combination tablet ledipasvir/sofosbuvir. American Association For The Study Of Liver Diseases. Boston, MA. ; 2014.