Ledipasvir/Tegobuvir/Vedroprevir + Digoxin = Precautionary

Effect on Concentration

Ledipasvir/Tegobuvir/Vedroprevir
Unknown
Applies within class?
No
Digoxin
Increase
Applies within class?
No

Pharmacologic Effects

Ledipasvir/Tegobuvir/Vedroprevir
Effect
N/A
Applies within class?
No
Digoxin
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Sources

ledipasvir/sofosbuvir vs pravastatin, rosuvastatin, gigoxin, or cyclosporine ^

Study Design

The drug-drug interaction potential of ledipasvir (LDV) in combination with vedroprevir (VDV) and tegobuvir (TGV) with pravastatin was evaluated.

Study Results

Co-administration of LDV/VDV/TGV and digoxin resulted in an increased Cmax and AUC by 25% and 34%, respectively, for digoxin.Close monitoring is advised for digoxin when it is co-administered with this combination due to its narrow therapeutic index.The lowest dose of digoxin should be initially prescribed. The serum digoxin concentrations should be monitored and used for titration of digoxin dose to obtain the desired clinical effect.

Study Conclusions

References

P German, Pang PS, L Fang, et al. Drug-drug interaction profile of the fixed dose combination tablet ledipasvir/sofosbuvir. American Association For The Study Of Liver Diseases. Boston, MA. ; 2014.