Saquinavir + Digoxin = Precautionary

Effect on Concentration

Saquinavir
Unknown
Applies within class?
No
Digoxin
Increase
Applies within class?
No

Pharmacologic Effects

Saquinavir
Effect
N/A
Applies within class?
No
Digoxin
Effect
N/A
Applies within class?
No

Interaction History

N/A

Last Updated 22-Nov-2022

Summary

Saquinavir/ritonavir (1000/100 mg po bid) significantly increased digoxin (0.5 mg IV once) AUC by 49% and Cmax of 27%. Digoxin doses should be reduced and digoxin concentration should be monitored when co-administered.

Sources

Digoxin vs saquinavir/r ^

Study Design

Study Results

Study Conclusions

References

B Kaeser, et al. Effect of saquinavir/ritonavir on the p-gp activity in healthy volunteers using digoxin as probe.abstract a-383. 46th Interscience Conference. . ; .